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The Formamidopyrimidine Derivative of 7-(2-Oxoethyl)-2′-deoxyguanosine

Vinyl chloride induces hepatic angiosarcomas, which are otherwise rare malignancies. The biochemical basis involves the formation of the epoxide, which reacts with DNA to give ~98% of the 7-(2-oxoethyl) adduct (4) of dGuo plus small amounts of the etheno derivatives of dGuo, dCyd, and dAdo. The carc...

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Bibliografiske detaljer
Main Authors: Christov, Plamen P., Kozekov, Ivan D., Rizzo, Carmelo J., Harris, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138534/
https://ncbi.nlm.nih.gov/pubmed/18690723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800142m
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