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Site-specific Synthesis and Characterization of Oligonucleotides Containing an N(6)-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine Lesion, the Ring-Opened Product from N7-Methylation of Deoxyguanosine
A phosphoramidite reagent of N(6)-(2-deoxy-d-erythro-pentofuranosyl)-2,6-diamino-1,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dGuo) lesions was synthesized in four steps from 2′-deoxyguanosine. Fapy nucleosides can rearrange to the pyranose form when the 5′-hydroxyl group is unprotected....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701371/ https://ncbi.nlm.nih.gov/pubmed/19053322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800352a |
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