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Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-β-d-erythro-pentofuranosyl)-imidazole-4-hydrazide
We report the synthesis of a new nucleoside, 1-(2-deoxy-β-d-erythro-pentofuranosyl)-imidazole-4-hydrazide (dY(NH(2))) as a reactive monomer for DNA diversification. The 5′-triphosphate derivative (dY(NH(2))TP, 1) was evaluated in vitro as a substrate for several DNA polymerases. Primer extension rea...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC113855/ https://ncbi.nlm.nih.gov/pubmed/11972322 |
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