Translesion DNA Synthesis by Human DNA Polymerase η on Templates Containing a Pyrimidopurinone Deoxyguanosine Adduct, 3-(2′-Deoxy-β-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one

[Image: see text] M(1)dG (3-(2′-deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one) lesions are mutagenic in bacterial and mammalian cells, leading to base substitutions (mostly M(1)dG to dT and M(1)dG to dA) and frameshift mutations. M(1)dG is produced endogenously through the reactio...

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Autores principales: Stafford, Jennifer B., Eoff, Robert L., Kozekova, Albena, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2008
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651650/
https://ncbi.nlm.nih.gov/pubmed/19108641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801591a
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