Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

Oxidation of endogenous macromolecules can generate electrophiles capable of forming mutagenic adducts in DNA. The lipid peroxidation product malondialdehyde, for example, reacts with DNA to form M(1)G, the mutagenic pyrimidopurinone adduct of deoxyguanosine. In addition to free radical attack of li...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Dedon, Peter C., Plastaras, John P., Rouzer, Carol A., Marnett, Lawrence J.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 1998
Aiheet:	Biological Sciences
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21604/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736698/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.19.11113
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