Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

Oxidation of endogenous macromolecules can generate electrophiles capable of forming mutagenic adducts in DNA. The lipid peroxidation product malondialdehyde, for example, reacts with DNA to form M(1)G, the mutagenic pyrimidopurinone adduct of deoxyguanosine. In addition to free radical attack of li...

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Autors principals: Dedon, Peter C., Plastaras, John P., Rouzer, Carol A., Marnett, Lawrence J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21604/
https://ncbi.nlm.nih.gov/pubmed/9736698
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