Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

Oxidation of endogenous macromolecules can generate electrophiles capable of forming mutagenic adducts in DNA. The lipid peroxidation product malondialdehyde, for example, reacts with DNA to form M(1)G, the mutagenic pyrimidopurinone adduct of deoxyguanosine. In addition to free radical attack of li...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Dedon, Peter C., Plastaras, John P., Rouzer, Carol A., Marnett, Lawrence J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1998
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21604/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736698/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.19.11113
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