Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

Oxidation of endogenous macromolecules can generate electrophiles capable of forming mutagenic adducts in DNA. The lipid peroxidation product malondialdehyde, for example, reacts with DNA to form M(1)G, the mutagenic pyrimidopurinone adduct of deoxyguanosine. In addition to free radical attack of li...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Dedon, Peter C., Plastaras, John P., Rouzer, Carol A., Marnett, Lawrence J.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1998
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21604/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736698/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.19.11113
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