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N(6)-(2-deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-(2-hydroxy-3-buten-1-yl)-formamidopyrimidine (EB-Fapy-dG) Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells
1,3-Butadiene (BD) is an environmental and occupational toxicant classified as a human carcinogen. BD is metabolically activated by cytochrome P450 monooxygenases to 3,4-epoxy-1-butene (EB), which alkylates DNA to form a range of nucleobase adducts. Among these, the most abundant are the hydrolytica...
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| Veröffentlicht in: | Chem Res Toxicol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6542698/ https://ncbi.nlm.nih.gov/pubmed/30016111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00123 |
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