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Synthesis of Oligonucleotides Containing the N(6)-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG) Oxidative Damage Product Derived from 2’-Deoxyguanosine
N(6)-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG) is a major DNA lesion produced from 2’-deoxyguanosine under oxidizing conditions. Fapy•dG is produced from a common intermediate that leads to 7,8-dihydro-8-oxo-2’-deoxyguanosine (8-OxodGuo), and in grea...
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| Publicado no: | Chemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7309192/ https://ncbi.nlm.nih.gov/pubmed/32271495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201905795 |
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