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The second coordination sphere of FIH controls hydroxylation
The factor inhibiting HIF (FIH) is a proximate oxygen sensor for human cells, hydroxylating Asn(803) within the α subunit of the hypoxia inducible factor (HIF). FIH is an α-ketoglutatrate (αKG) dependent, non-heme Fe(II) dioxygenase, in which Fe(II) is coordinated by a (His(2)Asp) facial triad, αKG,...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138472/ https://ncbi.nlm.nih.gov/pubmed/21456582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi102042t |
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