Synthesis and Activity of Thioether-Containing Analogues of the Complement Inhibitor Compstatin

Disulfide bonds are essential for the structural stability and biological activity of many bioactive peptides. However, these bonds are labile to reducing agents, which can limit the therapeutic utility of such peptides. Substitution of a disulfide bond with a reduction-resistant cystathionine bridg...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Knerr, Patrick J., Tzekou, Apostolia, Ricklin, Daniel, Qu, Hongchang, Chen, Hui, van der Donk, Wilfred A., Lambris, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137721/
https://ncbi.nlm.nih.gov/pubmed/21520911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2000378
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky