New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

Therapeutic modulation of the complement system has become increasingly important in line with the growing recognition of the role of complement in numerous diseases. Compstatin, a peptidic inhibitor that acts at the central level of the complement cascade, is currently in clinical evaluation but ro...

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Bibliografiske detaljer
Main Authors: Qu, Hongchang, Ricklin, Daniel, Bai, Hongjun, Chen, Hui, Reis, Edimara S., Maciejewski, Mateusz, Tzekou, Apostolia, DeAngelis, Robert A., Resuello, Ranillo R. G., Lupu, Florea, Barlow, Paul N., Lambris, John D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518557/
https://ncbi.nlm.nih.gov/pubmed/22795972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2012.06.003
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