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Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency(1)
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system. Compstatin and its derivatives have shown great promise for the treatment of many clinical disorders associated with unbalanced complement activity. To obtain more potent c...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014449/ https://ncbi.nlm.nih.gov/pubmed/21067811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.10.004 |
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