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Do mtDNA deletions drive premature aging in mtDNA mutator mice?

Deletions in mitochondrial DNA (mtDNA) have long been suspected to be involved in mammalian aging, but their role remains controversial. Recent research has demonstrated that relatively higher levels of mtDNA deletions correlate with premature aging in mtDNA mutator mice, which led to the conclusion...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kraytsberg, Yevgenya, Simon, David K., Turnbull, Douglas M., Khrapko, Konstantin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137638/
https://ncbi.nlm.nih.gov/pubmed/19416127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00484.x
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