Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis

The mtDNA mutator mouse lacks the proofreading capacity of the sole mtDNA polymerase, leading to accumulation of somatic mtDNA mutations, and a profound premature aging phenotype including elevated oxidative stress and apoptosis, and reduced mitochondrial function. We have previously reported that e...

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Detalhes bibliográficos
Publicado no:Curr Opin Genet Dev
Main Authors: Safdar, Adeel, Annis, Sofia, Kraytsberg, Yevgenya, Laverack, Chloe, Saleem, Ayesha, Popadin, Konstantin, Woods, Dori C, Tilly, Jonathan L, Khrapko, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592087/
https://ncbi.nlm.nih.gov/pubmed/27497229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2016.06.011
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