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On the timing and the extent of clonal expansion of mtDNA deletions: evidence from single-molecule PCR
mtDNA deletions are pathogenic mutations that remove substantial portions of the mitochondrial genome. mtDNA deletions accumulate with age and have been implicated in various degenerative diseases. There are multiple mtDNA per cell and mtDNA mutations become toxic only if they accumulate to substant...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724894/ https://ncbi.nlm.nih.gov/pubmed/19426731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.04.029 |
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