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On the timing and the extent of clonal expansion of mtDNA deletions: evidence from single-molecule PCR

mtDNA deletions are pathogenic mutations that remove substantial portions of the mitochondrial genome. mtDNA deletions accumulate with age and have been implicated in various degenerative diseases. There are multiple mtDNA per cell and mtDNA mutations become toxic only if they accumulate to substant...

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Detalhes bibliográficos
Main Authors: Nicholas, Alexander, Kraytsberg, Yevgenya, Guo, Xinhong, Khrapko, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724894/
https://ncbi.nlm.nih.gov/pubmed/19426731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.04.029
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