Repeats, longevity and the sources of mtDNA deletions: evidence from “deletional spectra”

Perfect direct repeats and, in particular, the prominent 13-bp repeat, are thought to cause mitochondrial DNA (mtDNA) deletions, which have been associated with the aging process. Accordingly, individuals lacking the 13-bp repeat are highly prevalent among centenarians and the number of repeats nega...

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Hlavní autoři: Guo, Xinhong, Popadin, Konstantin Yu., Markuzon, Natalya, Orlov, Yuriy L., Kraytsberg, Yevgenya, Krishnan, Kim. J., Zsurka, Gabor, Turnbull, Douglas M., Kunz, Wolfram S., Khrapko, Konstantin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915442/
https://ncbi.nlm.nih.gov/pubmed/20591530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2010.05.006
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