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Kinetic Modeling of Hyperpolarized (13)C Label Exchange between Pyruvate and Lactate in Tumor Cells

Measurements of the kinetics of hyperpolarized (13)C label exchange between [1-(13)C]pyruvate and lactate in suspensions of intact and lysed murine lymphoma cells, and in cells in which lactate dehydrogenase expression had been modulated by inhibition of the PI3K pathway, were used to determine quan...

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Autori principali: Witney, Timothy H., Kettunen, Mikko I., Brindle, Kevin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137032/
https://ncbi.nlm.nih.gov/pubmed/21596745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237727
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