Analysis of (13)C and (14)C labeling in pyruvate and lactate in tumor and blood of lymphoma‐bearing mice injected with (13)C‐ and (14)C‐labeled pyruvate

Measurements of hyperpolarized (13)C label exchange between injected [1‐(13)C]pyruvate and the endogenous tumor lactate pool can give an apparent first‐order rate constant for the exchange. The determination of the isotope flux, however, requires an estimate of the labeled pyruvate concentration in...

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Veröffentlicht in:NMR Biomed
Hauptverfasser: Serrao, E.M., Kettunen, M.I., Rodrigues, T.B., Lewis, D.Y., Gallagher, F.A., Hu, D.E., Brindle, K.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947589/
https://ncbi.nlm.nih.gov/pubmed/29457661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3901
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