Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-(13)C,U-(2)H]Lactate

[Image: see text] (13)C magnetic resonance spectroscopy and spectroscopic imaging measurements of hyperpolarized (13)C label exchange between exogenously administered [1-(13)C]pyruvate and endogenous lactate, catalyzed by lactate dehydrogenase (LDH), has proved to be a powerful approach for probing...

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Главные авторы: Kennedy, Brett W. C., Kettunen, Mikko I., Hu, De-En, Brindle, Kevin M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2012
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303201/
https://ncbi.nlm.nih.gov/pubmed/22316419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja300222e
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