Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function

Vesicular trafficking is crucial for bone resorption by osteoclasts, in particular for formation of the ruffled border membrane and for removal of the resultant bone degradation products by transcytosis. These processes are regulated by Rab family GTPases, whose activity is dependent on post-transla...

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Bibliografiska uppgifter
Huvudupphovsmän: Taylor, Adam, Mules, Emilie H, Seabra, Miguel C, Helfrich, Miep H, Rogers, Michael J, Coxon, Fraser P
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2011
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136943/
https://ncbi.nlm.nih.gov/pubmed/21776414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.3.16488
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