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Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet α- and δ-granule contents. Here we show by positional cloning that gm results from a G→A s...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Detter, John C., Zhang, Qing, Mules, Emilie H., Novak, Edward K., Mishra, Vishnu S., Li, Wei, McMurtrie, Elzbieta B., Tchernev, Velizar T., Wallace, Margaret R., Seabra, Miguel C., Swank, Richard T., Kingsmore, Stephen F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2000
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10737774/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.080517697
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