Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function

Vesicular trafficking is crucial for bone resorption by osteoclasts, in particular for formation of the ruffled border membrane and for removal of the resultant bone degradation products by transcytosis. These processes are regulated by Rab family GTPases, whose activity is dependent on post-transla...

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Autores principales: Taylor, Adam, Mules, Emilie H, Seabra, Miguel C, Helfrich, Miep H, Rogers, Michael J, Coxon, Fraser P
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2011
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136943/
https://ncbi.nlm.nih.gov/pubmed/21776414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.3.16488
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