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The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis. The polymerization of RAD51 is regulated by a number of RAD51 mediators, such as BRCA1, BRCA2, RAD52, SFR1, SWS1, and th...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136442/ https://ncbi.nlm.nih.gov/pubmed/21779174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002148 |
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