The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination

RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis. The polymerization of RAD51 is regulated by a number of RAD51 mediators, such as BRCA1, BRCA2, RAD52, SFR1, SWS1, and th...

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Main Authors: Qing, Yong, Yamazoe, Mitsuyoshi, Hirota, Kouji, Dejsuphong, Donniphat, Sakai, Wataru, Yamamoto, Kimiyo N., Bishop, Douglas K., Wu, XiaoHua, Takeda, Shunichi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136442/
https://ncbi.nlm.nih.gov/pubmed/21779174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002148
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