Similar Effects of Brca2 Truncation and Rad51 Paralog Deficiency on Immunoglobulin V Gene Diversification in DT40 Cells Support an Early Role for Rad51 Paralogs in Homologous Recombination

BRCA2 is a tumor suppressor gene that is linked to hereditary breast and ovarian cancer. Although the Brca2 protein participates in homologous DNA recombination (HR), its precise role remains unclear. From chicken DT40 cells, we generated BRCA2 gene-deficient cells which harbor a truncation at the 3...

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Detalhes bibliográficos
Main Authors: Hatanaka, Atsushi, Yamazoe, Mitsuyoshi, Sale, Julian E., Takata, Minoru, Yamamoto, Kazuhiko, Kitao, Hiroyuki, Sonoda, Eiichiro, Kikuchi, Koji, Yonetani, Yasukazu, Takeda, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544004/
https://ncbi.nlm.nih.gov/pubmed/15657438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.3.1124-1134.2005
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