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Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
Sequencing studies are increasingly being conducted to identify rare variants associated with complex traits. The limited power of classical single-marker association analysis for rare variants poses a central challenge in such studies. We propose the sequence kernel association test (SKAT), a super...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135811/ https://ncbi.nlm.nih.gov/pubmed/21737059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.05.029 |
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