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Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

Sequencing studies are increasingly being conducted to identify rare variants associated with complex traits. The limited power of classical single-marker association analysis for rare variants poses a central challenge in such studies. We propose the sequence kernel association test (SKAT), a super...

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Detalhes bibliográficos
Main Authors: Wu, Michael C., Lee, Seunggeun, Cai, Tianxi, Li, Yun, Boehnke, Michael, Lin, Xihong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135811/
https://ncbi.nlm.nih.gov/pubmed/21737059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.05.029
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