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Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

Sequencing studies are increasingly being conducted to identify rare variants associated with complex traits. The limited power of classical single-marker association analysis for rare variants poses a central challenge in such studies. We propose the sequence kernel association test (SKAT), a super...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wu, Michael C., Lee, Seunggeun, Cai, Tianxi, Li, Yun, Boehnke, Michael, Lin, Xihong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135811/
https://ncbi.nlm.nih.gov/pubmed/21737059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.05.029
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