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Optimal tests for rare variant effects in sequencing association studies
With development of massively parallel sequencing technologies, there is a substantial need for developing powerful rare variant association tests. Common approaches include burden and non-burden tests. Burden tests assume all rare variants in the target region have effects on the phenotype in the s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440237/ https://ncbi.nlm.nih.gov/pubmed/22699862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxs014 |
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