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Optimal tests for rare variant effects in sequencing association studies

With development of massively parallel sequencing technologies, there is a substantial need for developing powerful rare variant association tests. Common approaches include burden and non-burden tests. Burden tests assume all rare variants in the target region have effects on the phenotype in the s...

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Bibliografiske detaljer
Main Authors: Lee, Seunggeun, Wu, Michael C., Lin, Xihong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440237/
https://ncbi.nlm.nih.gov/pubmed/22699862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxs014
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