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Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecules of nonobese diabetic (N...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135372/ https://ncbi.nlm.nih.gov/pubmed/21690251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110574 |
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