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Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
Regulatory T cells (T reg cells) are essential for the prevention of autoimmunity throughout life. T reg cell development occurs intrathymically but a subset of T reg cells can also differentiate from naive T cells in the periphery. In vitro, Smad signaling facilitates conversion of naive T cells in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428940/ https://ncbi.nlm.nih.gov/pubmed/22908322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112646 |
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