Selective depletion of Foxp3(+) regulatory T cells induces a scurfy-like disease

The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...

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Bibliografiske detaljer
Main Authors: Lahl, Katharina, Loddenkemper, Christoph, Drouin, Cathy, Freyer, Jennifer, Arnason, Jon, Eberl, Gérard, Hamann, Alf, Wagner, Hermann, Huehn, Jochen, Sparwasser, Tim
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Brief Definitive Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118432/
https://ncbi.nlm.nih.gov/pubmed/17200412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061852
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