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Selective depletion of Foxp3(+) regulatory T cells induces a scurfy-like disease
The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118432/ https://ncbi.nlm.nih.gov/pubmed/17200412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061852 |
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