Development Of Foxp3(+) Regulatory T Cells Is Driven By A c-Rel Enhanceosome

Regulatory T (Treg) cells play essential roles in maintaining immune homeostasis. While Foxp3 expression marks the commitment of progenitors to Treg lineage, how Treg cells are generated during lymphocyte development remains enigmatic. Both NFAT and Smad have been implicated in Foxp3 gene activation...

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Detalhes bibliográficos
Main Authors: Ruan, Qingguo, Kameswaran, Vasumathi, Tone, Yukiko, Li, Li, Liou, Hsiou-Chi, Greene, Mark I., Tone, Masahide, Chen, Youhai H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807990/
https://ncbi.nlm.nih.gov/pubmed/20064450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.10.006
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