The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

The Th17 cells use the retinoid-related orphan receptor-γ (Rorg or Rorc) to specify their differentiation and lineage-specific function. However, how Rorg is switched on during Th17 differentiation is unknown. We report here that c-Rel and RelA/p65 transcription factors drive Th17 differentiation by...

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Bibliografiske detaljer
Main Authors: Ruan, Qingguo, Kameswaran, Vasumathi, Zhang, Yan, Zheng, Shijun, Sun, Jing, Wang, Junmei, DeVirgiliis, Jennifer, Liou, Hsiou-Chi, Beg, Amer A., Chen, Youhai H.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201209/
https://ncbi.nlm.nih.gov/pubmed/22006976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110462
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