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Transcriptional regulation of the Th17 immune response by IKKα

Th17 cells are a subset of T cells that play crucial roles in the pathogenesis of many inflammatory diseases. We report here the identification of IKKα (inhibitor of NF-κB kinase-α) as a key transcriptional regulator of the Th17 lineage. T cells expressing a nonactivatable form of IKKα were signific...

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Detalhes bibliográficos
Main Authors: Li, Li, Ruan, Qingguo, Hilliard, Brendan, DeVirgiliis, Jennifer, Karin, Michael, Chen, Youhai H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135338/
https://ncbi.nlm.nih.gov/pubmed/21402739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091346
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