Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecules of nonobese diabetic (N...

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Bibliographic Details
Main Authors: Daniel, Carolin, Weigmann, Benno, Bronson, Roderick, von Boehmer, Harald
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135372/
https://ncbi.nlm.nih.gov/pubmed/21690251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110574
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