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Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes

In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not develop diabetes. Howev...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Apostolou, Irina, Hao, Zhenyue, Rajewsky, Klaus, von Boehmer, Harald
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2003
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194221/
https://ncbi.nlm.nih.gov/pubmed/14530378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030698
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