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Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes
In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not develop diabetes. Howev...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194221/ https://ncbi.nlm.nih.gov/pubmed/14530378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030698 |
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