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T Cell–specific Ablation of Fas Leads to Fas Ligand–mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis

To study the role of Fas–Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination. Experiments in which Fas was ablated in T cells, B cells, T and B cells, or in a...

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Detalhes bibliográficos
Main Authors: Hao, Zhenyue, Hampel, Brigitte, Yagita, Hideo, Rajewsky, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211818/
https://ncbi.nlm.nih.gov/pubmed/15148335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032196
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