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Effects of glycosylation on the stability and flexibility of a metastable protein: the human serpin α(1)-antitrypsin
Protein glycosylation commonly stabilizes proteins thereby increasing protein half-lives and protecting against denaturation or proteolytic degradation. While generally beneficial, such stabilization is potentially disadvantageous in the case of inhibitory serpins. These protease inhibitors are meta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134971/ https://ncbi.nlm.nih.gov/pubmed/21765645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.08.003 |
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