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Local and Global Effects of a Cavity Filling Mutation in a Metastable Serpin
The serpins are an unusual class of protease inhibitors which fold to a metastable form and subsequently undergo a massive conformational change to a stable form when they inhibit their target proteases. The driving force for this conformational change has been extensively investigated by site direc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746415/ https://ncbi.nlm.nih.gov/pubmed/19624115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900342d |
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