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Folding mechanism of the metastable serpin α(1)-antitrypsin

The misfolding of serpins is linked to several genetic disorders including emphysema, thrombosis, and dementia. During folding, inhibitory serpins are kinetically trapped in a metastable state in which a stretch of residues near the C terminus of the molecule are exposed to solvent as a flexible loo...

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Detalhes bibliográficos
Main Authors: Tsutsui, Yuko, Dela Cruz, Richard, Wintrode, Patrick L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311335/
https://ncbi.nlm.nih.gov/pubmed/22392975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109125109
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