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Folding mechanism of the metastable serpin α(1)-antitrypsin
The misfolding of serpins is linked to several genetic disorders including emphysema, thrombosis, and dementia. During folding, inhibitory serpins are kinetically trapped in a metastable state in which a stretch of residues near the C terminus of the molecule are exposed to solvent as a flexible loo...
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| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311335/ https://ncbi.nlm.nih.gov/pubmed/22392975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109125109 |
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