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Mechanism of 1,N(2)-Etheno-2′-deoxyguanosine Formation from Epoxyaldehydes()
Background levels of etheno adducts have been attributed to the reaction of DNA with 2,3-epoxyaldehydes, a proposed product of lipid peroxidation. We have examined the reaction of (2R,3S)-epoxyhexanal with dGuo to give 7-(1S-hydroxybutyl)-1,N(2)-etheno-dGuo. We observed that the stereochemistry of t...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133930/ https://ncbi.nlm.nih.gov/pubmed/17907786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7001433 |
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