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Site Specific Synthesis and Polymerase Bypass of Oligonucleotides Containing a 6-Hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one Base, an Intermediate in the Formation of 1N(2)-Etheno-2′-deoxyguanosine

The reaction of DNA with certain bis-electrophiles such as chlorooxirane and chloroacetaldehyde produces etheno adducts. These lesions are highly miscoding, and some of the chemical agents that produce them have been shown to be carcinogenic in laboratory animals and in humans. An intermediate in th...

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Detaylı Bibliyografya
Asıl Yazarlar: Goodenough, Angela K., Kozekov, Ivan D., Zang, Hong, Choi, Jeong-Yun, Guengerich, F. Peter, Harris, Thomas M., Rizzo, Carmelo J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135970/
https://ncbi.nlm.nih.gov/pubmed/16300379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx050141k
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