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Mechanism of 1,N(2)-Etheno-2′-deoxyguanosine Formation from Epoxyaldehydes()

Background levels of etheno adducts have been attributed to the reaction of DNA with 2,3-epoxyaldehydes, a proposed product of lipid peroxidation. We have examined the reaction of (2R,3S)-epoxyhexanal with dGuo to give 7-(1S-hydroxybutyl)-1,N(2)-etheno-dGuo. We observed that the stereochemistry of t...

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Autori principali: Petrova, Katya V., Jalluri, Ravikumar S., Kozekov, Ivan D., Rizzo, Carmelo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133930/
https://ncbi.nlm.nih.gov/pubmed/17907786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7001433
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