BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

Caspase-8 stably inserts into the mitochondrial outer membrane during extrinsic apoptosis. Inhibition of caspase-8 enrichment on the mitochondria impairs caspase-8 activation and prevents apoptosis. However, the function of active caspase-8 on the mitochondrial membrane remains unknown. In this stud...

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Bibliografiska uppgifter
Huvudupphovsmän: Schug, Z T, Gonzalvez, F, Houtkooper, R H, Vaz, F M, Gottlieb, E
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132005/
https://ncbi.nlm.nih.gov/pubmed/21072056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.135
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