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BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane
Caspase-8 stably inserts into the mitochondrial outer membrane during extrinsic apoptosis. Inhibition of caspase-8 enrichment on the mitochondria impairs caspase-8 activation and prevents apoptosis. However, the function of active caspase-8 on the mitochondrial membrane remains unknown. In this stud...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3132005/ https://ncbi.nlm.nih.gov/pubmed/21072056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.135 |
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